Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1
C Zhao, DH Yu, R Shen, GS Feng - Journal of Biological Chemistry, 1999 - ASBMB
We describe a novel human adapter molecule containing a pleckstrin homolgy (PH) domain
at the N terminus that is closely related to human Grb2-associatedbinder 1, Gab1, and
Drosophila daughter of sevenless. We designate this protein as Gab2. Northern blot
analysis indicates that Gab2 is widely expressed and has an overlapping but distinctive
expression pattern as compared with Gab1, with high levels of Gab2 mRNA detected in the
heart, brain, placenta, spleen, ovary, peripheral blood leukocytes, and spinal cord. Upon …
at the N terminus that is closely related to human Grb2-associatedbinder 1, Gab1, and
Drosophila daughter of sevenless. We designate this protein as Gab2. Northern blot
analysis indicates that Gab2 is widely expressed and has an overlapping but distinctive
expression pattern as compared with Gab1, with high levels of Gab2 mRNA detected in the
heart, brain, placenta, spleen, ovary, peripheral blood leukocytes, and spinal cord. Upon …
