Brain metastases are a common complication of systemic cancers, occurring in more than
100,000 patients per year. 121 Metastases to the brain are the commonest intracranial
tumors, outnumbering primary brain tumors by at least 10 to 1. In the 1980s and 1990s,
significant advancements were made in the diagnosis and treatment of brain metastases.
Although the development of brain metastases still usually indicates a poor prognosis for the
patient, it is now possible to reverse most of the symptoms of brain metastases and improve …