Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH: implications for atherosclerotic …
SL Schissel, X Jiang, J Tweedie-Hardman… - Journal of Biological …, 1998 - ASBMB
The subendothelial aggregation and retention of low density lipoprotein (LDL) are key
events in atherogenesis, but the mechanisms in vivo are not known. Previous studies have
shown that treatment of LDL with bacterial sphingomyelinase (SMase) in vitro leads to the
formation of lesion-like LDL aggregates that become retained on extracellular matrix and
stimulate macrophage foam cell formation. In addition, aggregated human lesional LDL, but
not unaggregated lesional LDL or plasma LDL, shows evidence of hydrolysis by an arterial …
events in atherogenesis, but the mechanisms in vivo are not known. Previous studies have
shown that treatment of LDL with bacterial sphingomyelinase (SMase) in vitro leads to the
formation of lesion-like LDL aggregates that become retained on extracellular matrix and
stimulate macrophage foam cell formation. In addition, aggregated human lesional LDL, but
not unaggregated lesional LDL or plasma LDL, shows evidence of hydrolysis by an arterial …
