Inhibitory effects of central neuropeptide Y on the somatotropic and gonadotropic axes in male rats are independent of adrenal hormones
A Sainsbury, H Herzog - Peptides, 2001 - Elsevier
Neuropeptide Y (NPY) in the hypothalamus exerts multiple physiological functions including
stimulation of adipogenic pathways such as feeding and insulin secretion as well as
inhibition of the somatotropic and gonadotropic axes. Since hypothalamic NPY-ergic activity
is increased by negative energy balance, NPY enables coordinated regulation of growth
and reproduction in parallel with energy availability. Chronic pathological increases in
central NPY-ergic activity contribute to obesity. Many of the adipogenic effects of NPY are …
stimulation of adipogenic pathways such as feeding and insulin secretion as well as
inhibition of the somatotropic and gonadotropic axes. Since hypothalamic NPY-ergic activity
is increased by negative energy balance, NPY enables coordinated regulation of growth
and reproduction in parallel with energy availability. Chronic pathological increases in
central NPY-ergic activity contribute to obesity. Many of the adipogenic effects of NPY are …
