Increased numbers of CCR5+ interferon‐γ– and tumor necrosis factor‐α–secreting T lymphocytes in multiple sclerosis patients
T Strunk, S Bubel, B Mascher… - Annals of Neurology …, 2000 - Wiley Online Library
T Strunk, S Bubel, B Mascher, P Schlenke, H Kirchner, KP Wandinger
Annals of Neurology: Official Journal of the American Neurological …, 2000•Wiley Online LibraryTo determine the frequency of in vivo activated TH1 lymphocytes, T‐cell subsets of 9
multiple sclerosis patients with active disease and 17 healthy controls were analyzed by
immunostaining for CCR5, CD26, and their expression of interleukin‐2, interferon‐γ, and
tumor necrosis factor‐α. The numbers of CCR5+ interferon‐γ–and tumor necrosis factor‐α–
producing T cells were significantly increased in the peripheral blood of multiple sclerosis
patients. CCR5 expression may be a useful marker to identify effector cells in multiple …
multiple sclerosis patients with active disease and 17 healthy controls were analyzed by
immunostaining for CCR5, CD26, and their expression of interleukin‐2, interferon‐γ, and
tumor necrosis factor‐α. The numbers of CCR5+ interferon‐γ–and tumor necrosis factor‐α–
producing T cells were significantly increased in the peripheral blood of multiple sclerosis
patients. CCR5 expression may be a useful marker to identify effector cells in multiple …
Abstract
To determine the frequency of in vivo activated TH1 lymphocytes, T‐cell subsets of 9 multiple sclerosis patients with active disease and 17 healthy controls were analyzed by immunostaining for CCR5, CD26, and their expression of interleukin‐2, interferon‐γ, and tumor necrosis factor‐α. The numbers of CCR5+ interferon‐γ– and tumor necrosis factor‐α–producing T cells were significantly increased in the peripheral blood of multiple sclerosis patients. CCR5 expression may be a useful marker to identify effector cells in multiple sclerosis and could be used as a tool for monitoring disease activity. Ann Neurol 2000;47:269–273
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