Modulation of leukocyte-mediated myocardial reperfusion injury
BR Lucchesi - Annual review of physiology, 1990 - annualreviews.org
BR Lucchesi
Annual review of physiology, 1990•annualreviews.orgNew therapeutic interventions, such as coronary angioplasty or thrombolytic therapy, are
directed towards the treatment of acute myocardial ischemia based upon the recognition that
mortality among patients who are evolving a myocardial infarction is influenced by the extent
of left ventricular dysfunc tion, which is directly related to the amount of myocardium that
becomes infarcted and thus non-functional (1). Secondly, the size of the infarct that results is
related directly to the severity and duration of the ischemic interval.
directed towards the treatment of acute myocardial ischemia based upon the recognition that
mortality among patients who are evolving a myocardial infarction is influenced by the extent
of left ventricular dysfunc tion, which is directly related to the amount of myocardium that
becomes infarcted and thus non-functional (1). Secondly, the size of the infarct that results is
related directly to the severity and duration of the ischemic interval.
New therapeutic interventions, such as coronary angioplasty or thrombolytic therapy, are directed towards the treatment of acute myocardial ischemia based upon the recognition that mortality among patients who are evolving a myocardial infarction is influenced by the extent of left ventricular dysfunc tion, which is directly related to the amount of myocardium that becomes infarcted and thus non-functional (1). Secondly, the size of the infarct that results is related directly to the severity and duration of the ischemic interval.
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