Copper deficiency in a genetically hypertensive cardiomyopathic rat: electrocardiogram, functional and ultrastructural aspects
DM Medeiros, Z Liao, RL Hamlin - The Journal of nutrition, 1991 - Elsevier
The effect of copper deficiency on cardiac function and structure was studied in a strain of
rats (SHHS/Mcc-cp) known to develop cardiac failure as adults. Restriction of dietary copper
(≤ 1 mg/kg vs. 6 mg/kg in adequate diets) at weaning in both sexes for a 6-wk period
produced cardiac hypertrophy. Male rats developed more severe copper-deficiency
symptoms than their female counterparts. In both sexes of copper-deficient rats, there was
an increase in cardiac length, width, free ventricular wall thickness and septum thickness …
rats (SHHS/Mcc-cp) known to develop cardiac failure as adults. Restriction of dietary copper
(≤ 1 mg/kg vs. 6 mg/kg in adequate diets) at weaning in both sexes for a 6-wk period
produced cardiac hypertrophy. Male rats developed more severe copper-deficiency
symptoms than their female counterparts. In both sexes of copper-deficient rats, there was
an increase in cardiac length, width, free ventricular wall thickness and septum thickness …
