[HTML][HTML] Fibroblast growth factor-2 suppression of tumor necrosis factor α-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase
AM Gardner, GL Johnson - Journal of Biological Chemistry, 1996 - ASBMB
Treatment of L929 cells with tumor necrosis factor α (TNFα) activates a programmed cell
death pathway resulting in apoptosis. We investigated the intracellular signaling pathways
activated in L929 cells by TNFα. TNFα robustly activates Jun kinase (JNK), a member of the
mitogen-activated protein kinase (MAPK) family. In addition, p42 MAPK is activated, but a 10-
fold greater concentration of TNFα was required for substantial MAPK activation than was
needed for maximal JNK stimulation. Simultaneous treatment of L929 cells with fibroblast …
death pathway resulting in apoptosis. We investigated the intracellular signaling pathways
activated in L929 cells by TNFα. TNFα robustly activates Jun kinase (JNK), a member of the
mitogen-activated protein kinase (MAPK) family. In addition, p42 MAPK is activated, but a 10-
fold greater concentration of TNFα was required for substantial MAPK activation than was
needed for maximal JNK stimulation. Simultaneous treatment of L929 cells with fibroblast …
