Bisphosphonates are pyrophosphate analogues in which the oxygen bridge has been replaced by a carbon with various side chains (PCP). These compounds have been known to the chemists since the 19th century, the first synthesis dating back to 1865 (1). They were first used in various industrial procedures, among others as anticorrosive and antiscaling agents (2). After discovering that they can effectively control calcium phosphate formation and dissolution in vitro (3, 4), as well as mineralization and bone resorption in vivo (3, 4), they were developed and used in the treatment of bone diseases, mostly Paget’s disease, hypercalcemia of malignancy, and, lately, osteoporosis (for review see reference 5).