[HTML][HTML] Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma …
The initial site of melanoma cell metastasis is frequently the regional lymph nodes, and the
appearance of lymph node metastasis correlates with poor prognosis. Lymph node
adhesion is mediated by an interaction between the tumor cell integrin αvβ3 and lymph
node vitronectin. In this study, we explored the relationship between adhesion and
proteolysis by examining the direct effect of vitronectin receptor ligation on matrix
metalloproteinase-2 (MMP-2) production by B16F1 and B16F10 melanoma cells. We report …
appearance of lymph node metastasis correlates with poor prognosis. Lymph node
adhesion is mediated by an interaction between the tumor cell integrin αvβ3 and lymph
node vitronectin. In this study, we explored the relationship between adhesion and
proteolysis by examining the direct effect of vitronectin receptor ligation on matrix
metalloproteinase-2 (MMP-2) production by B16F1 and B16F10 melanoma cells. We report …