Extracellular ATP and UTP induce chloride secretion in nasal epithelia of cystic fibrosis patients and normal subjects in vivo
METHODS Nine normal subjects (6 F, 3 M; age 18 to 28 years) and 12 CF patients (7 F, 5 M;
age 19 to 38 years) were studied. The same 5 normal subjects and 5 CF patients were
studied at all concentrations in the dose-response studies. Specimens for cell culture were
obtained from nasal tissue excised from 5 CF patients and 4 normal subjects undergoing
clinically indicated operations. The nasal potential difference (PD) and response to
superfusion with amiloride and/or chloride-free solution and/or nucleotide (or nucleoside) …
age 19 to 38 years) were studied. The same 5 normal subjects and 5 CF patients were
studied at all concentrations in the dose-response studies. Specimens for cell culture were
obtained from nasal tissue excised from 5 CF patients and 4 normal subjects undergoing
clinically indicated operations. The nasal potential difference (PD) and response to
superfusion with amiloride and/or chloride-free solution and/or nucleotide (or nucleoside) …