[HTML][HTML] Regulation of Epithelial Sodium Channels by the Cystic Fibrosis Transmembrane Conductance Regulator (∗)
II Ismailov, MS Awayda, B Jovov, BK Berdiev… - Journal of Biological …, 1996 - ASBMB
Cystic fibrosis airway epithelia exhibit enhanced Na+ reabsorption in parallel with
diminished Cl-secretion. We tested the hypothesis that the cystic fibrosis transmembrane
conductance regulator (CFTR) directly affects epithelial Na+ channel activity by co-
incorporating into planar lipid bilayers immunopurified bovine tracheal CFTR and either
heterologously expressed rat epithelial Na+ channel (α, β, γ-rENaC) or an immunopurified
bovine renal Na+ channel protein complex. The single channel open probability (P 0) of …
diminished Cl-secretion. We tested the hypothesis that the cystic fibrosis transmembrane
conductance regulator (CFTR) directly affects epithelial Na+ channel activity by co-
incorporating into planar lipid bilayers immunopurified bovine tracheal CFTR and either
heterologously expressed rat epithelial Na+ channel (α, β, γ-rENaC) or an immunopurified
bovine renal Na+ channel protein complex. The single channel open probability (P 0) of …