Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study
K Janssen, RP Mensink, FJ Cox, JL Harryvan… - The American journal of …, 1998 - Elsevier
Intake of dietary flavonols and flavones was inversely associated with risk for cardiovascular
disease in several epidemiologic studies. This may have been due to effects on hemostasis
because flavonoids have been reported to inhibit platelet aggregation in vitro. We indeed
found that 2500 micromol/L of the flavonol quercetin and the flavone apigenin significantly
inhibited collagen-and ADP-induced aggregation in platelet-rich plasma and washed
platelets by approximately 80-97%. However, lower concentrations, such as might occur in …
disease in several epidemiologic studies. This may have been due to effects on hemostasis
because flavonoids have been reported to inhibit platelet aggregation in vitro. We indeed
found that 2500 micromol/L of the flavonol quercetin and the flavone apigenin significantly
inhibited collagen-and ADP-induced aggregation in platelet-rich plasma and washed
platelets by approximately 80-97%. However, lower concentrations, such as might occur in …