A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey
KE Asin, L Bednarz, AL Nikkel, PA Gore Jr… - Pharmacology …, 1992 - Elsevier
The anorectic actions of cholecystokinin (CCK)-8 and of a selective CCK-A agonist, A-
71623, were examined in CD1 mice, beagle dogs, and cynomolgous monkeys. A-71623
suppressed intakes in all species tested, and the effects were blocked by a selective CCK-A
antagonist, A-70104. In the dog only, CCK-8 was more potent on a molar basis compared to
A-71623, although the effects of both CCK agonists were more short-lived in the dog
compared to the other species tested. Our results support other evidence suggesting that the …
71623, were examined in CD1 mice, beagle dogs, and cynomolgous monkeys. A-71623
suppressed intakes in all species tested, and the effects were blocked by a selective CCK-A
antagonist, A-70104. In the dog only, CCK-8 was more potent on a molar basis compared to
A-71623, although the effects of both CCK agonists were more short-lived in the dog
compared to the other species tested. Our results support other evidence suggesting that the …
