Anti-self/tumor T cell function can be improved by increasing TCR-peptide MHC (pMHC) affinity within physiological limits, but paradoxically further increases (
Michael Hebeisen, Lukas Baitsch, Danilo Presotto, Petra Baumgaertner, Pedro Romero, Olivier Michielin, Daniel E. Speiser, Nathalie Rufer
Levels of ZAP-70 and ERK 1/2 phosphorylation in SUP-T1 and CD8+ T cells engineered with TCRs of incremental affinities.