Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We generated mice with endothelial-specific, inducible expression of an
Yong Deng, Deepak Atri, Anne Eichmann, Michael Simons
Inhibition of ERK signaling rescues the lymphatic phenotype in